Effects of Omega-3 Fatty Acids on Pentylenetetrazole-induced Kindling, Cognitive Impairment and Oxidative Stress
نویسندگان
چکیده
Epilepsy as well as chronic use of most antiepileptic drugs, particularly in children, predisposes to cognitive impairment. The brain is considered abnormally sensitive to oxidative stress and damage which observed during seizure activity. Omega-3 (OM3) fatty acids are known antioxidants that play a role in nervous system activity, cognitive development, memory-related learning, and synaptic transmission. Aim: The aim of the present study was to investigate the protective effects of OM3 on cognitive impairment after development of seizures and corresponding oxidative stress and neuronal DNA damage in young pentylenetetrazole (PTZ)-kindled rats. Methods: The effect of pretreatment with OM3 (200, 300 and 500 mg/kg, orally) on PTZ-induced kindling, corresponding cognitive impairment, using passive avoidance test, hippocampal oxidative stress. Furthermore, the corresponding changes in hippocampal 8-hydroxy-2′-deoxyguanosine (8-OHdG) were measured. Results: PTZ, (30 mg/kg, i.p.) once every alternate day induced kindling in rats after 31.0±1.4 days. OM3 showed dose-dependent anti-seizure effect. OM3 significantly increased the latency to myoclonic jerks, clonic seizures as well as generalized tonic-clonic seizures, and decreased the number of myoclonic jerks. PTZ kindling induced a significant oxidative stress and cognitive impairment which was reversed by pretreatment with OM3 in a dose-dependent manner. In addition, hippocampal 8-OHdG levels were significantly reduced by OM3 in PTZ kindled rats. Conclusions: OM3 ameliorates seizures, cognitive impairment, oxidative stress and hippocampal DNA damage in PTZ kindled rats. These results thus suggest the potential of OM3 as an adjuvant in epilepsy both to prevent seizures as well as to protect against seizure induced memory impairment. [Basel A. Abdel-Wahab, Samy M. Abd El-Aziz, and Jobran M. Al-Qahtani. Effects of Omega-3 Fatty Acids on Pentylenetetrazole-induced Kindling, Cognitive Impairment and Oxidative Stress. Life Sci J 2014;11(7):186196]. (ISSN:1097-8135). http://www.lifesciencesite.com. 23
منابع مشابه
The ameliorative effects of sesamol against seizures, cognitive impairment and oxidative stress in the experimental model of epilepsy
Objective(s):A growing interest has recently been attracted towards the identification of plant-based medications including those with protective effects against cognitive impairment. Sesamol has shown promising antioxidant and neuroprotective effects, therefore, we aimed to evaluate its therapeutic potential in epilepsy which is commonly associated with oxidative stress and cognitive impairmen...
متن کاملEffect of Short and Long-Term Treatment with Omega-3 Fatty Acids on Scopolamine-Induced Amnesia
Two omega-3 fatty acids including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are essential for the physiologic function of neuronal cell membrane. Normal function of neuronal cell membrane requires appropriate composition of fatty in its structure. Present study was designed to compare the effect of short-term and long-term pretreatment with omega-3 fatty acids on scopolamine...
متن کاملEffect of Short and Long-Term Treatment with Omega-3 Fatty Acids on Scopolamine-Induced Amnesia
Two omega-3 fatty acids including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are essential for the physiologic function of neuronal cell membrane. Normal function of neuronal cell membrane requires appropriate composition of fatty in its structure. Present study was designed to compare the effect of short-term and long-term pretreatment with omega-3 fatty acids on scopolamine...
متن کاملThe ameliorative effects of sesamol against seizures, cognitive impairment and oxidative stress in the experimental model of epilepsy
OBJECTIVE(S) A growing interest has recently been attracted towards the identification of plant-based medications including those with protective effects against cognitive impairment. Sesamol has shown promising antioxidant and neuroprotective effects, therefore, we aimed to evaluate its therapeutic potential in epilepsy which is commonly associated with oxidative stress and cognitive impairmen...
متن کاملPharmacological Studies on Khamira Marwarid: Effect on Pentylenetetrazole-Induced Seizures, Cognition and Biochemical Markers in Mice
Cognitive impairment in epileptics may be a consequence of the epileptogenic process as well as antiepileptic medication. Thus, there is need for drugs, which can suppress epileptogenesis as well as prevent cognitive impairment. In the present study, the effect of Khamira Marwarid (KAH 1 ), a formulation based on Indian system of Unani medicine, was evaluated on the course of pentylenetetrazole...
متن کامل